一、基本信息
李新林,男,博士,现任乐宝体育中国官方网站助理研究员,主要从事天然药物的发现与化学生物学研究。
通讯地址:山东省济南市文化西路44号山东大学齐鲁医学院乐宝体育中国官方网站,邮编250012
联系方式(Email):xinlinli@sdu.edu.cn
个人主页:https://www.researchgate.net/profile/Xin-Lin-Li
https://faculty.sdu.edu.cn/lixinlin/zh_CN/
二、研究方向
1.特殊生境微生物来源的活性天然产物挖掘和发现
2.天然产物的生物合成与合成生物学开发
三、教育和工作经历
教育经历:
2019.09 - 2023.06中国科学院大学(中国科学院分子植物科学卓越创新中心)理学博士(生物化学与分子生物学,师从王成树研究员)
2016.09 - 2019.07首都医科大学医学硕士(中药学,师从高伟教授)
2010.09 - 2014.07天津中医药大学理学学士(中药资源与开发)
工作经历:
2023.09~至今,乐宝体育中国官方网站,助理研究员
四、代表性论文(6篇)(#共同一作,*通讯作者)
[1]Xin-Lin Li, Yanlei Sun, Ying Yin, Shuai Zhan, Chengshu Wang*. (2023). A bacterial-like Pictet-Spenglerase drives the evolution of fungi to produce β-carboline glycosides together with separate genes.Proceedings of the National Academy of Sciences of the United States of America, 120, e2303327120.
[2]Xin-Lin Li#, Yu-Xing Xu#, Yuan Li, Rui Zhang, Tian-Yuan Hu, Ping Su, Man Zhou, Ting Tang, Ying Zeng, Yan-Long Yang*, Wei Gao*. (2019). Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining.Fungal Genetics and Biology, 128, 36-42.
[3] Yanlei Sun#, Bo Chen#,Xin-Lin Li, Ying Yin, Chengshu Wang*. (2022). Orchestrated biosynthesis of the secondary metabolite cocktails enables the producing fungus to combat diverse bacteria.mBio, 13, e0180022.
[4] Yuan Li,Xin-Lin Li, Chang-Jiang-Sheng Lai, Rui-Shan Wang, Li-Ping Kang, Ting Ma, Zhen-Hua Zhao, Wei Gao*, Lu-Qi Huang*. (2019). Functional characterization of three flavonoid glycosyltransferases from Andrographis paniculata.Royal Society Open Science, 6, 190150.
[5] Tianyuan Hu, Jiawei Zhou, Yuru Tong, Ping Su,Xin-Lin Li, Yuan Liu, Nan Liu, Xiaoyi Wu, Yifeng Zhang, Jiadian Wang, Linhui Gao, Lichan Tu, Yun Lu, Zhouqian Jiang, Yongjin J Zhou, Wei Gao*, Luqi Huang*. (2020). Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast.Metabolic Engineering, 60, 87-96.
[6] Yuan Li, Hui-Xin Lin, Jian Wang, Jian Yang, Chang-Jiang-Sheng Lai, Xing Wang, Bao-Wei Ma, Jin-Fu Tang, Yong Li,Xin-Lin Li, Juan Guo, Wei Gao*, Lu-Qi Huang*. (2018). Glucosyltransferase capable of catalyzing the last step in Neoandrographolide biosynthesis.Organic Letters, 20, 5999-6002.
五、获奖和荣誉
获评中国科学院大学三好学生(2021 - 2022学年)