Hengchang Zang
PERSONAL DATA:
Born: March, 1964
Citizenship: China
Senior engineer at a level of research worker
Professor of Pharmaceutical Engineering
Dean, Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences
ADDRESS
School of Pharmaceutical Sciences
Shandong University,
No.44, Wenhuaxi Road, Jinan 250012
P.R.China
Tel/Fax: 86-531-88380268
E-mail: zanghcw@126.com
PRESENT POSITION
Committee member, Sub-committee on Ministry of Education in Pharmaceutical Engineering, Ministry of Education.
Assistant Director and Secretary-general, Branch of Industrial Biochemistry and Molecular Biology, Chinese Society of Biochemistry and Molecular Biology.
Assistant Director, China Instrument Instrument Society Drug Quality Analysis and Process Control Branch
Director, China society of Biochemistry and molecular biology.
Committee member,China Pharmaceutical Association Pharmaceutical Management Professional Committee.
Executive director, Near Infrared Spectral Branch of China Instrument Instrument Society.
Expert member, Second Expert Committee of China Biochemical Pharmaceutical Industry Association.
Academician, International Society of Near Infrared spectroscopy.
First academician, International Society of Aquaphotomics.
Director, Shandong Pharmaceutical Society Pharmaceutical Engineering Professional Committee
Deputy director, Shandong Provincial Pharmaceutical Association's Specialized Committee on Biochemical and Biotechnology Drugs.
Director, China Instrument Instrument Society Near Infrared Spectrum Branch Shandong Workstation.
EDUCATION BACKGROUND
2010.07-2013.06, Ph.D. in Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
1987.09-1990.06, M.S. in Department of Pharmacy, Shandong Medical University, Jinan, China.
1981.09-1985.06, B.S. in Department of Pharmacy, Shandong Medical University, Jinan, China.
RESEARCH FIELD
Direction of Pharmaceutical engineering:
1. Studies on the common problems of pharmaceutical field by near infrared spectroscopy, process analysis technology (PAT) pharmaceutical process application research, intelligent quality control research
2. Research on the basis of TCM curative effect substance and its transfer rule, production process analysis, quality evaluation and quality process control.
3. Research on the process of blood products and biological drugs, optimization and control and information management.
4. Research on the continuous production of drugs.
Direction of drug policy and drug administration:
1. Research on pharmaceutical supply chain.
2. Research on the compliance of drug production process.
In recent years, our research group has been devoted to the theoretical exploration and application research of the application of near-infrared spectroscopy in the pharmaceutical field.
RESEARCH FOUNDING
Scientific research task
National science and technology major project "demonstration study on integration of advanced pharmacy and information technology of oral Chinese medicine preparation", No. 2018ZX09201010.
National science and technology major special project "research on new product development and key technologies for industrialization of coagulant subclasses", No. 2014ZX09508003.
National Major Scientific Instrument and Equipment Development Project of "Development and application of grating near infrared analyzer and its Shared model", No. 2014YQ470377.
863 program (Hi-tech research and development program of China), NO.2012AA021505.
Shandong province Major scientific and technological innovation project, Key technology of intelligent control of sustained-release solid drug preparation process, No. 2018CXGC1405.
Shandong natural science foundation. A new modeling strategy for on-line quality analysis of blood products based on near infrared spectroscopy, No. ZR2017MB012.
Shandong province Industrialization projects of major innovative drugs, No.2012CX20203.
Shandong province independent innovation achievements transformation major project, No.2010ZHZX1A0406.
Science and technology development program of shandong province, No.2009GG10002081.
Horizontal project "research on key technologies for industrialization of near-infrared spectral pharmaceutical analysis module", No.11611413.
Horizontal project "technical research and development of evaluation method of curative effect substances in the production process of qilong capsule", No.11611722.
Horizontal project "online analysis and application of near-infrared spectroscopy for solid preparation equipment", No. 11611610.
Teaching and research projects
Research on the new mode of cultivating "multi-dimensional" generic basic platform of pharmaceutical engineering, No. 2018Y02.
Shandong province postgraduate education innovation plan project "exploration of full-time professional master training mode in pharmaceutical engineering", No. SDYY10006.
Shandong province projects of higher education reform, No. 2009131.
RECENT PUBLICATION
Zhongyu Sun, Can Li, Lian Li, Lei Nie, Qin Dong, Danyang Li, Lingling Gao, Hengchang Zang*. Study on feasibility of determination of glucosamine content of fermentation process using a micro NIR spectrometer. Spectrochim Acta A. 2018(201): 153-160.
Zhongyu Sun, Jiayue Wang, Lei Nie, Lian Li, Dawei Cao, Jiajin Fan, Haiyan Wang, Ruichen Liu, Yinran Zhang, Hengchang Zang*. Calibration transfer of near infrared spectrometers for the assessment of plasma ethanol precipitation process. Chemometrics and Intelligent Laboratory Systems. 181 (2018) 64-71.
Ronghua Liu, Qiaofeng Sun, TianHu , Lian Li , Lei Nie , JiayueWang , Wanhui Zhou, Hengchang Zang*. Multi-parameters monitoring during traditional Chinese medicine concentration process with near infrared spectroscopy and chemometrics. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2018, 192: 75-81.
Jiayue Wang, Tongtong Li, Hailong Yang, Tian Hu, Lei Nie, Fei Wang, Manel Alcalà, and Hengchang Zang*. Geographical origin discrimination and polysaccharides quantitative analysis of radix codonopsis with micro near-infrared spectrometer engine. Journal of Innovative Optical Health Sciences. 2018, 11(2):185004(1-11)
Jiayue Wang, Tongtong Li, Hailong Yang, Tian Hu, Lei Nie, Fei Wang, Manel Alcalà, and Hengchang Zang*. Geographical origin discrimination and polysaccharides quantitative analysis of radix codonopsis with micro near-infrared spectrometer engine. Journal of Innovative Optical Health Sciences. 2018, 11(2):185004(1-11)
Ronghua Liu, Lian Li, Wenping Yin, Dongbo Xu, Hengchang Zang*. Near-infrared spectroscopy monitoring and control of the fluidized bed granulation and coating processes-A review. International Journal of Pharmaceutics. 2017, 530: 308-315.
Tian Hu, Tongtong Li, Lei Nie, Lixuan Zang, Hengchang Zang* and Yingzi Zeng. Rapid monitoring the water extraction process of Radix Paeoniae Alba using near infrared spectroscopy. Journal of Innovative Optical Health Sciences. 2017,(10) 6 :1750002 (8 pages).
Can Li , Fei Wang, Lixuan Zang, Hengchang Zang*, Manel Alcalà, Lei Nie , Mingyu Wang, Lian Li. Near infrared spectroscopy combined with multivariate analysis for monitoring the ethanol precipitation process of fraction I + II + III supernatant in human albumin separation. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2017 (175) :17-23.
Qingli Guo, Lei Nie, Lian Li, Hengchang Zang*. Estimation of the Critical Quality Attributes for Hydroxypropyl Methylcellulose With Near-Infrared Spectroscopy and Chemometrics. Spectrochim Acta A Mol Biomol Spectrosc, 2017(177): 158-163.
Zhigang Song, Peixue Ling, Hengchang Zang*, Lian Li, Jinfeng Wang, Yan Jin, Huarong Shao, Xiqiang Zhu, Fei Liu, Fengshan Wang. Development, validation and influence factor analysis of anear-infrared method for the molecular weight determinationof xanthan gum[J]. Carbohydrate Polymers, 2015, 115: 582-588.
Pei Wang, Hui Zhang, Hailong Yang, Lei Nie, Hengchang Zang*. Rapid determination of major bioactive isoflavonoid compounds during the extraction process of kudzu (Pueraria lobata) by near-infrared transmission spectroscopy[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 137: 1403-1407.
Xiaoju Duan, Danlu Zhang, Lei Nie, Hengchang Zang*. Rapid discrimination of geographical origin and evaluation of antioxidant of Salvia miltiorrhiza var. alba by Fourier transform near infrared spectroscopy[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 122: 751-757
Tian Hu, Hailong Yang, Hengchang Zang*. Absolutely nondestuctive discrimination of huoshan dendrobium nobile species with miniature near-infrared (NIR) spectrometer engine[J]. Spectroscopy and Spectral Analysis, 2014, 34 (10): 2802-2814.
L. Li, B. Ding, Q. Yang, S. Chen, H. Ren, J. Wang, H. Zang*, F. Wang, L. Zang. The relevance study of effective information between near infrared spectroscopy and chondrotin sulfate in ethanol precipitation process [J]. Journal of Innovative Optical Health Sciences, 2014, 7 (6): 1450022-1-7.
Q. Dong, H. Zang*, L. Zang, et al. Rapid determination of hyaluronic acid concentration in fermentation broth with near-infrared spectroscopy [J]. Journal of Innovative Optical Health Sciences, 2014, 7(6).
H. Zhang, A. Liu, H. Zang*, H. Li, W. Jiang, L. Li, J. Wang, Rapid determination of immunoglobulin G concentration in cold ethanol precipitation process of raw plasma with near-infrared spectroscopy, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 116: 370-373.
Zang, J. Wang, L. Li, H. Zhang, W. Jiang, F. Wang﹡, Application of near-infrared spectroscopy combined with multivariate analysisin monitoring of crude heparin purification process, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 109: 8-13.
P. Wang, L. Li, H. Yang, S. Cheng, Y. Zeng, L. Nie, H. Zang*, Chromatographic fingerprinting and quantitative analysis for the quality evaluation of Xinkeshu Tablet, Journal of Pharmaceutical Analysis, 2012, 53: 274-278.
H. Zang, L. Li, F. Wang﹡, Q. Yi, Q. Dong, C. Sun, J. Wang, A method for identifying the origin of chondroitin sulfate with near infrared spectroscopy, Journal of pharmaceutical and biomedical analysis, 2012, 61：224-229.
Q. Dong, H. Zang*, A. Liu, G. Yang, C. Sun, L. Sui, P. Wang, L. Li, Determination of molecular weight of hyaluronic acid by near-infrared spectroscopy, Journal of pharmaceutical and biomedical analysis, 2010, 53: 274-278.
C. Sun, H. Zang*, X. Liu, Q. Dong, L. Li, F. Wang, L. Sui, Determination of potency of heparin active pharmaceutical ingredient by near infrared reflectance spectroscopy, Journal of pharmaceutical and biomedical analysis, 2010, 51: 1060-1063.
H. Zhang, A. Liu, H. Zang*, X. Guo, T. Zhang, Research process in low molecular weight hyaluronic acid preparation and Bioactivity, Chinese Pharmaceutical Journal, 2012, 47: 1022-1024.
H. Zhang, A. Liu, H. Zang*, X. Guo, Research progress in fermentation process with near infrared spectroscopy, Chinese Journal of Biochemical Pharmaceutics, 2012, 33: 689-691.
H. Zang*, Q. Dong, F. Wang, A. Liu, Review on the molecular weight determination methods of glycosaminoglycans, Chinese Journal of Biochemical Pharmaceutics, 2012, 32(6): 490-493.
D. Sun, H. Zang*, Application of Near-infrared Spectroscopy in Pharmaceutical Solid Preparation Analysis, Food and Drug, 2012, 14: 139-143.
Y. Li, H. Zang*, N. Zhang, G. Zhai, L. Li, Compound materials used for Direct compression and its application prospects, Pharmaceutical Biotechnology, 2012, 19: 177-180.
P. Wang, H. Zang*, Y. Zeng, Quality risk causes and control of pharmaceutical production process, Chinese Pharmaceutical Journal, 2011, 46: 969-972.
L. Li, H. Zang*, C. Sun, Research process on production technique of chondroitin sulfate, Chinese Journal of Biochemical Pharmaceutics, 2011, 32(5): 415-417.
C. Sun, H. Zang*, Q. Dong, F. Wang, T. Zhang, Measurement methods of Oversulfated chondroitin sulfate in heparin sodium, Chinese Journal of Pharmaceutical Analysis, 2010, 2: 352-355.
Q. Dong, H. Zang*, A. Liu, T. Zhang, C. Sun, Study on the application of process analytical technology in the pharmaceutical field and its enlightenment on China pharmaceutical industry, Chinese Pharmaceutical Journal, 2010, 12: 881-884.
ZANG Hengchang, SUN Chun-xiao. Prospect on application of near-infrared spectroscopy in glycosaminoglycan analysis[J]. Chinese Journal of Biochemical Pharmaceutics, 2009, 30(1): 55-57.
PATENTS
A method for monitoring the precipitation process of human serum albumin acetate buffer by near infrared spectroscopy, No. ZL201610640261.9.
A rapid determination of moisture content in people blood coagulation factor Ⅷ finished product, No. 201510148952.2.
A method for detecting the fingerprinting of Xinkeshu preparation, No. 201110033061.4.
A method for rapid determination of hyaluronic acid content, No. 201110212477.2.
A method for identifying the origin of chondroitin sulfate, No. 201010559937.4.
Caffeoyl naphthalene sulfonamide compound and its preparation method and activity of anti-HIV integrase enzyme, No. CN03138909.0
TALENT CULTIVATION
Currently, there are 7 doctoral candidates, including 3 engineering doctoral candidates. There are 11 full-time postgraduate students in the school of pharmacy, and 2 postgraduate students in the medical and health management and pharmaceutical management direction; Has graduated full-time master graduate student 25 people.There are 12 engineering master students. Has graduated master of engineering graduate 107 people.
INTERNATIONAL EXCHANGE
1. International conference on Aquaphotomics, Osaka, Japan
2. The 18th international near infrared spectroscopy annual conference, Copenhagen, Denmark
3. Cooperation and exchange in pharmaceutical management of university of Sussex, UK
4. Academic visit and exchange at autonomous university of Barcelona, Spain
5. Fourth European academic conference on process analysis and control, graz, Austria
6. The 23rd IFPAC international conference, Maryland, USA
7. JDSU (USA) conducts academic exchanges on near-infrared spectroscopy
8. 4th Asian near infrared spectroscopy annual conference, daegu, Korea
9. The 17th international near infrared spectroscopy annual conference, iguazu, Brazil
10. The 16th international near infrared spectroscopy annual conference, montpellier, France
11. Cape Town, South Africa, 15th international near infrared spectroscopy annual conference
