School of Pharmaceutical Sciences Shandong University, Jinan 250012, China
Tel/Fax: 86-0531－8832015
Email: zkyjd@sdu.edu.cn
Present Position:
Professor of Pharmaceutics
Director of Department of Pharmaceutics
Education Background:
2004.10-2007.02: Postdoctor, School of Pharmaceutical Sciences, Shandong University
199.09-2003.09: Ph D, School of Pharmaceutical Sciences, Shenyang Pharmaceutical University
1993.09-1996.07: M. Sci., School of Pharmaceutical Sciences, Shandong Medical University
1986.09- 1990.07: B. Sci., School of Pharmaceutical Sciences, Shandong Medical University
Professional Experience:
2009.09-Present: Professor of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University
2001.09-2009.08: Associate Professor of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University
2007.03-2008.03: Visiting scholar in School of Pharmaceutical Sciences, Ohio State University
2003.04-2003.11: New Drug Registration Expert, Center for Drug Evaluation (CDE), State Food and Drug Administration (SFDA)
1996.07-2001.09: Lecturer, School of Pharmaceutical Sciences, Shandong Medical University
1990.07-1993.09: Pharmacist, Stomatological Hospital of Shandong Medical University
Teaching Courses:
Pharmaceutics; Modern Pharmaceutical Preparation Technology; Industrial Pharmaceutics
Research Interests:
(1) Sustained-Release, Controlled-Release and Targeted Drug Delivery System
(2) Transdermal Drug Delivery System and Nasal Drug Delivery System
(3) Biomedical Materials and Biological Drugs Drug Delivery System
(4) Research on Promoting the in vivo Absorption of Macromolecular Drug and Poorly Water-soluble Drug
Research Grant Support:
Currently Active:
The National Natural Science Foundation of China (Grant No. 30973646)
Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
Shandong Provincial Natural Science Foundation (ZR2011HM026)
Grants Completed:
Independent Innovation Foundation of Shandong University, IIFSDU (2010JC018)
Scientific and Technological Issue, Department of Shandong Science and Technology, PR China (Grant No. 2008GG10002012).
Scientific and Technological Issue, Department of Shandong Science and Technology, PR China (Grant No.2006GG2202053).
Excellent Young Scientists' Fund of Shandong Province, P.R.China (Grant No. 2004BS03019)
Young Scientists' Star Plan Fund of Jinan, Shandong Province, P.R.China (Grant No. 50116)
Patents:
1. A preparation of curcumin nanocrystals and its preparation method (ZL2008101399418.9)
2. A preparation of curcumin self-microemulsion and its preparation method (ZL200510042547.9)
3. A preparation of quercetin solid lipid nanoparticles and its preparation method (ZL 200610044416.9)
4. A preparation of penciclovir microemulsion-based gels and its preparation method (ZL 200810014048.2)
5. A preparation of curcumin gelatin microspheres and its preparation method (ZL 200810159648.8)
6. A spray preparation of low molecular weight heparin liposome and its preparation method (ZL 96116044.6)
7. An oral preparation of puerarin and its preparation method (ZL 02135329.8)
Recent Publications:
Wang S, Chen P, Zhang L, Yang C, Zhai G*.Formulation and evaluation of micro- emulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin. J Drug Target. 2012, 20(10):831-40.
Gao Y, Wang C, Sun M, Wang X, Yu A, Li A, Zhai G*. In vivo evaluation of curcumin loaded nanosuspensions by oral administration. J Biomed Nanotechnol. 2012, 8(4): 659-68.
Sun M, Su X, Ding B, He X, Liu X, Yu A, Lou H, Zhai G*.Advances in nanotechnology- based delivery systems for curcumin. Nanomedicine (Lond). 2012,7(7):1085-100.
Tan Q, Liu X, Fu X, Li Q, Dou J, Zhai G*. Current development in nanoformulations of docetaxel. Expert Opin Drug Deliv. 2012,9(8):975-90.
Zhao L, Du J, Duan Y, Zang Y, Zhang H, Yang C, Cao F, Zhai G*.Curcumin loaded mixed micelles composed of Pluronic P123 and F68: preparation, optimization and in vitro characterization. Colloids Surf B Biointerfaces. 2012, 97:101-8.
Zhang L, Zhu W, Yang C, Guo H, Yu A, Ji J, Gao Y, Sun M, Zhai G*. A novel folate- modified self-microemulsifying drug delivery system of curcumin for colon targeting. Int J Nanomedicine. 2012, 7:151-62
Chen H, Wu J, Sun M, Guo C, Yu A, Cao F, Zhao L, Tan Q, Zhai G*. N-trimethyl chitosan chloride-coated liposomes for the oral delivery of curcumin. J Liposome Res. 2012, 22(2):100-9.
Ding B, Li T, Zhang J, Zhao L, Zhai G*.Advances in liver-directed gene therapy for hepatocellular carcinoma by non-viral delivery systems. Curr Gene Ther. 2012,12 (2):92-102
Tan Q, Liu W, Guo C, Zhai G. Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery. Int J Nanomedicine. 2011,6: 1621-30.
Song Z, Feng R, Sun M, Guo C, Gao Y, Li L, Zhai G*.Curcumin-loaded PLGA-PEG- PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo. J Colloid Interface Sci. 2011, 354(1):116-23.
Yu A, Wang H, Wang J, Cao F, Gao Y, Cui J, Zhai G*. Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. J Pharm Sci. 2011, 100(3):933-41.
Gao Y, Li Z, Sun M, Guo C, Yu A, Xi Y, Cui J, Lou H, Zhai G*. Preparation and characterization of intravenously injectable Curcumin nanosuspension. Drug Deliv. 2011, 18(2): 131-42.
Sun M, Gao Y, Pei Y, Guo C, Li H, Cao F, Yu A, Zhai G*. Development of nanosuspension formulation for oral delivery of quercetin. J Biomed Nanotechnol. 2010, 6(4):325-32.
Yu A, Guo C, Zhou Y, Cao F, Zhu W, Sun M, Zhai G*. Skin irritation and the inhibition effect on HSV-1 in vivo of penciclovir-loaded microemulsion. Int Immunopharmacol. 2010, 10 (10): 1305-9.
Guo C, Wang J, Cao F, Lee RJ, Zhai G*.Lyotropic liquid crystal systems in drug delivery. Drug Discov Today. 2010,15(23-24):1032-40.
Gao Y, Wang Y, Ma Y, Yu A, Cai F, Shao W, Zhai G*. Formulation optimization and in situ absorption in rat intestinal tract of quercetin-loaded Microemulsion. Colloids and Surfaces B: Biointerfaces, 2009, 71 (2):30-314.
Li H, Zhao X, Ma Y, Zhai G*, Li L, Lou H. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Release. 2009, 133 (3): 238-44.
Lv Q, Yu A, Xi Y, Li H, Song Z, Cui J, Cao F, Zhai G.*. Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery. Int J Pharm. 2009, 372(1-2): 191-199
Cui J, Yu B, Zhao Y, Zhu W, Li H, Lou H, Zhai G*. Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. Int J Pharm. 2009, 371 (1-2):148-55
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