Wenfang XU
College of Pharmacy Shandong University
44, West Culture Road, Ji’nan, 250012
Phone: 86-531-88382264, Fax: 86-531-88382264
E-mail: xuwenf@sdu.edu.cn
Wenfang Xu graduated from Nanjing College of Pharmacy in 1978. Now he is a distinguished professor, Ph D teacher, Director of Medicinal Chemistry Institute of School of Pharmaceutical Sciences in Shandong University. He is also a distinguished young and middle-aged expert in Shandong province, chief-editor of national program teaching book 《Medicinal Chemistry》《Drug Design》. The main research field and interests are the rational drug design, synthesis and bio-evaluation based on bio-targets.
Professional Experience
2008-present,distinguished professor, College of Pharmacy, Shandong University
1997-2008,Professor and Dean, College of Pharmacy, Shandong University
1991-1997,Associate Professor, College of Pharmacy, Shandong Medical University
1986-1991,Assistant Professor, College of Pharmacy, Shandong Medical University
1983-1986,Teaching Assistant, College of Pharmacy, Shandong Medical University
1978-1983,Research Assistant, School of Pharmacy, China Pharmaceutical University
since 1988,Professional intercommunion in Italy, Switzerland, Japan, Spain，U.S.A etc as Invited Scholar
Research Grants
National High Technology Research and Development Program of China (863 project; Grant No 2007AA02Z314)
The Major Research Plan of the National Natural Science Foundation of China (Grant No. 90713041).
The National Natural Foundation Research Grant. (Grant No. 30772654; No 36072541)
The Doctoral Foundation of Ministry of Education of the People’s Republic of China (Grant No. 20060422029).
The Shandong Province Foundation Research Grant. (Grant No. Y2004C02)
Honors and Awards
Technological Advancement Award of Ministry of Education P.R.C, 2006
The National Superexcellent Teacher,2004
Famous Teaching Master in Shandong University,2004
Technological Advancement Award of Shandong Province,2002
Technological Advancement Award of Ministry of Education P.R.C2002,
Technological Advancement Award of Shandong Province 2001
The labor Award for Jinan City, 1999
Technological Advancement Award of Shandong Province, 1999
Technological Advancement Award of Shandong Province, 1998
Memberships in Professional Societies
Member of National Anticancer Society for Anticancer Agent Division, 1998-
Expert of SFDA for New Drugs Evaluation Committee, 1998-
Member of National Pharmaceutical Society for Medicinal Chemistry Division, 2000-
Expert of National Medicinal Textbook Evaluation Committee, 2001-
Associate Chief Member, Chinese Ministry of Education didactical Guidance Committee for Pharmaceutical Engineering Division, 2001-
Member of Shandong University Academic Committee for Medicine, 2004-
Chief Member of Shandong Province Pharmaceutical Society, 2004-
Member of American Chemical Society, 2003-
Member of Society of Chinese Bioscientists in America, 2006-
Reviewer for Journal Manuscripts
Journal of Shandong University (Health Sciences), 1999-
Journal of Chinese Medicinal Chemistry, 2002-
Journal of Cancer Prevention and Treatment, 2005-
Recent Patents on Anti-cancer Drug Discovery, 2006-
Anti-cancer Agents in Medicinal Chemistry,2006-
Journal of Intern Pharm Research,2007-
Journal of Food and Drug,2007
Special Invited Reviewer for Bioorg Med Chem and
Journal of Intern Pharmaceutics, 2004-
Books
Xu, Wenfang. Experimental Methodology of Medicinal Chemistry, People’s Medical Publishing House, 2010
Xu, Wenfang. “Drug Design” , People’s Medical Publishing House, 2007
Xu, Wenfang. “Medicinal Chemistry” , China Higher Education Press，2006
Xu, Wenfang; “The Principles and Methods of New Drug Design” 1st Edition, China Medical Science and Technology Publishing House, 1997
Xu, Wenfang. “Medicinal Chemistry” , People’s Medical Publishing House, 2000
Xu, Wenfang. “Design and Development for New Drugs” 1st Edition, Science Publishing House, 2001
Xu, Wenfang. “Pharmaceutical Conspectus” 1st Edition, China Medical Science and Technology Publishing House, 2002
Xu, Wenfang. “National Professional Apothecary Convocation Tutorship”1st Edition, Beijing Technology Publishing House, 2003
Publication Recently
Shang L, Fang H, Zhu H, Wang X, Wang Q, Mu J, Wang B, Kishioka S, Xu W*. Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors. Bioorg Med Chem. 2009, 17(7): 2775-84.（SCI）
Li Q, Fang H, Wang X, Hu L, Xu W*. Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I. Eur J Med Chem. 2009, 1-7.
Zhang L, Fang H, Xu W*. Strategies in developing promising histone deacetylase inhibitors. Med Res Rev. 2009, in press.（SCI）
Mou J, Fang H, Jing F, Wang Q, Liu Y, Zhu H, Shang L, Wang X, Xu W*. Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors. Bioorg Med Chem. 2009, 17(13): 4666-73.（SCI）
Yang K, Wang Q, Su L, Fang H, Wang X, Gong J, Wang B, Xu W*. Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors. Bioorg Med Chem. 2009, 17(11): 3810-7.（SCI）
Xian-Chao Cheng, Qiang Wang, Hao Fang and Wen-Fang Xu*. Advances in Matrix Metalloproteinase Inhibitors Based on Pyrrolidine Scaffold. Current Medicinal Chemistry, 2008, 15 (4), 374-385
Xian-Chao Cheng, Qiang Wang, Hao Fang, Zi-Yao Tang, Wen-Fang Xu *. Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors. European Journal of Medicinal Chemistry，2008 1-10
Xian-Chao Cheng, Hao Fang & Wen-Fang Xu*. Advances in assays of matrix metalloproteinases (MMPs) and their Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 23 (2), 154-167
Xian-Chao Cheng, Qiang Wang, Hao Fang, Wei Tang, Wen-Fang Xu*. Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors. Bioorganic & Medicinal Chemistry, 2008
Jie Zhang, Wenfang Xu*, Guanhua Du. Synthesis, inhibitory activity and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors. Bioorganic & Medicinal Chemistry, 2008, 16(9): 3839-3847
Jie Zhang, Wenfang Xu*, Ailin Liu, Guanhua Du, Design, synthesis, preliminary evaluation of new pyrrolidine derivatives as neuraminidase inhibitors. Medicinal Chemistry, 2008, 4(3): 206~209.
Qiang wang, Maoying chen, Huawei zhu, Jie zhang, Hao fang, Binghe wang, Wenfang Xu*.Design Synthesis and QSAR Studies of Novel Lysine Derives as Aminopeptidase N/CD13 Inhibitors. Bioorganic & Medicinal Chemistry, 2008,16(10)
Huawei zhu, Hao fang, Luyao wang, Wenxiang hu, Wenfang Xu*. 3D-QSAR Study with Pharmacophore-based Molecular Alignment of Hydroxamic acid-related Phosphinates that are Aminopeptidase N Inhibitors, Drug Discov Ther 2008; 2(1):52-57
Yepeng Luan, jiajia Mu and Wenfang Xu*, The Review of the Synthesis of Bestatin an Effective Inhibitor of Aminopeptidase N, Mini-Rev Org Chem 2008,5:134-140
Xian-Chao Cheng, Qiang Wang, Hao Fang andWen-Fang Xu *. Role of Sulfonamide Group in Matrix Metalloproteinase Inhibitors. Current Medicinal Chemistry, 2008, 15 (4), 368-373
Yingjie Li and Wenfang Xu*, Progress on Kinesin Spindle Protein Inhibitors as Anticancer Agents, Anti-cancer Agents Med. Chem, 2008,8
Luqing Shang, Takehiko meala Wenfang Xu and Shiroki Kishioka, J Enz. Inhib. Med. Chem. 2008;23(2)
Jie Zhang, Qiang Wang, Hao Fang, Wenfang Xu*, Ailin Liu, Guanhua Du. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorg Med Chem. 2007;15(7):2749-58.
Jianzhi Gong, Wenfang Xu*, Jie Zhang. Structure and functions of influenza virus neuraminidase. Curr Med Chem. 2007;14(1):113-22.
Qianbin. Li, Hao. Fang, Wenfang Xu*, Novel 3-Galloylamido-N’-substituded- 2,6-piperidinedione-Nacetamide Peptidomimetics as Metalloproteinase Inhibitors, Bioorg. Med. Chem Lett. 2007, 17(10), 2935-2938
Yepeng Luan, Wenfang Xu*. The structure and main functions of Aminopeptidase N. Current Med Chem. 2007, 14, 639-647.
Yu Liu, Jie Zhang, Wenfang Xu*. Recent progress in design and synthesis of neuraminidase inhibitors. Curr Med Chem. 2007，14(27):2872-2891
XIAN-CHAO CHENG, HAO FANG & WEN-FANG XU*.Advances in assays of matrix metalloproteinases (MMPs) and their inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2007; 00(0): 1–14
Feng-Zhi Liu, Hao Fang, Hua-Wei Zhu, Qiang Wang, and Wen-Fang Xu. Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)- pyrrolidine derivatives as potential iNOS inhibitors. Bioorganic & Medicinal Chemistry , 2008,
Xian-Chao Cheng, Xin-Yong Liu, Wen-Fang Xu, Xiu-Li Guo and Yang Ou. Design, synthesis and biological activities of novel Ligustrazine derivatives. Bioorganic & Medicinal Chemistry 2007; 15: 3315–3320
Xin Yong LIU*, Ren Zhang YAN, Nian Gen CHEN, Wen Fang XU . Regioselective Synthesis and Anti-HIV Activity of the Novel 2- and 4-Substituted Pyrazolo[4,5-e][1,2,4]thiadiazines. Chin. Chem. Lett. 2007;18: 137-140
Jingde Wu, Xinyong Liu *, Xianchao Cheng, Yuan Cao, Defeng Wang , Zhong Li, Wenfang Xu, Christophe Pannecouque, Myriam Witvrouw and Erik De Clercq. Synthesis of Novel Derivatives of 4-Amino-3-(2-Furyl)-5-Mercapto-1,2,4-Triazole as Potential HIV-1 NNRTIs . Molecules， 2007, 12, 2003-2016
Xian-jun QU, Shu-xiang CUI, Zhigang TIAN, Xun LI, Ming-hui CHEN, Wen-fang XU*,Yoshinori Inagaki, Ying-bing Deng, Masatoshi Makuuchi, Munehiro NAKATA and Wei TANG: Antineoplaston A10 Inhibits Human Hepatocellula Carcinoma Cells Growth through Induction of Apoptosis Anticancer Res, 2007, 27: 2427-2432.
Jian Liu, Xun Li, Yan-na Cheng, Shu-xiang Cui, Ming-hui Chen, Wen-fang Xu,Zhi-gang Tian, Masatoshi Makuuchi, Wei Tang a,d, Xian-jun Qu：Inhibition of human gastric carcinoma cell growth by treatment of N3-o-toluyl-fluorouracil as a precursor of 5-fluorouracil. Eur J Pharmacol. 2007 Nov 21; 574(1):1-7.
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