Date of birth: July 14, 1976, Shandong Province, China
Gender: Female
Citizenship: P. R. China
Address: Department of Medicinal Chemistry
School of Pharmaceutical Science, Shandong University
No 44, West Culture Road, Ji’nan, 250012, China
Tel: 86-531-88382005; Fax: 86-531-88382264; Cell Phone: 86-0-13287758928
E-mail: tjulx2004@sdu.edu.cn
EDUCATIONAL BACKGROUND
1999--2004 Ph.D. Department of Chemistry, Shandong University (1999-2001), and School of Pharmaceutical Science and Technology, Tianjin University (2001-2004)
1995--1999 B.S. Department of Chemistry, Qufu Normal University
PROFESSIONAL EXPERIENCE
2004--2006 Lecturer & Postdoctoral Fellow, College of Pharmacy, Shandong University
2006--present Associate Professor, College of Pharmacy, Shandong University
2007.06--2007.08 Visiting Scholar, The Tokyo University, Japan
2008.07--2008.10 Visiting Scholar, The Tokyo University, Japan
HONORS AND AWARDS
Award of Excellent Postdoctoral Research Fellowship of China, 2005
Award of Youth Research Fellowship of 40th IUPAC, 2005
Award of Excellent Postdoctoral Research Fellowship of Shandong Province, 200
Award of Youth Research Fellowship of 2nd Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics (JCMWDDT) 2008
The Second-Class Shandong Province Science and Technology Progress Award, No four, 2012
TEACHING EXPERIENCE
2005--present Inorganic Chemistry
2005--present Coordination Chemistry
2005--present Elemental Chemistry
GRANTS
2013.10~2016.10 The Natural Foundation Research Grant of Shandong Province: “Anti-tumor study based on the oxazoline peptidomimetics” (Grant No. ZR2013HM101)
2008.01~2010.12 The National Natural Foundation Research Grant: “Design, Synthesis and MDR reversal activity evaluation of quinoxalinone derivatives” (Grant No. 30701053)
2007.01~2009.12 The Youth Doctoral Foundation of Ministry of Education of China: “Design, Synthesis and anti-tumor study of Micro-molecular peptidomimetics as APNIs” (Grant No. 20070422061).
2008.01~2008.12The China-Japan Collaborative Research Grant: “Anti-hepatoma activity of pyrrolidine derivatives” No 103 Japan-China Medical Association, Tokyo, Japan.
2008.12~2011.12 The Natural Foundation Research Grant of Shandong Province: “Anti-tumor study based on the APN (CD13)” (Grant No. Y2008C01)
2005.01~2007.12 The Youth Foundation Research Grant of Shandong Province: “Design, Synthesis and MDR reversal study of P-pg inhibitors” (Grant No. 2005BS11005).
2006.01~2008.12 Science planning project of Shandong Province: “Anti-tumor research of TFU” (Grant No. 20061305).
2009.12~2011.12 The Independent Innovation Fund of Shandong University “Design, Synthesis and anti-tumor evaluation of peptidomimetics as MMPIs” (2009TS113)
INVITED LECTURES PRESENTED AT CONFERENCES
Xun Li. Design, synthesis and anti-tumor research of peptidomimetic MMPIs. 40th IUPAC Conference. 2005, Aug. 14~19 (Beijing).
Xun Li. Design, Synthesis and Evaluation of Micro-molecular Peptidomimetics as APN inhibitors (APNIs). China-Japan Joint Medical Workshop on Drug Discoveries and Therapeutics. 2007, May. 26~30 (Ji’nan, Shandong Province)
PATENTS
Xun Li, Hongyu Yuan, Wenfang Xu “Quinoxalinone derivatives with MDR reversal activity”. Patent No: ZL 200910020091.4
Xun Li, Yonggang Li “Quinoxalinone derivatives as MMP inhibitors” Patent No: ZL 200910229537.4
Xun Li, Yonggang Li “Quinoxalinone peptidomimetics as MMP inhibitors” Patent No: CN200910229538.9
Xun Li, Leilei Shi, Jianfeng Zhou, Zhiyu Li, Wenfang Xu, Xuemei Han “The preparation and Application of Quinoxalinone amide” Patent No: CN102863397A
Xun Li, Hengchang Zang, Leilei Shi, “Facile and eco-friend Preparation of 2,3,5-trimethylbenzoquinone（TMBQ）” Patent No: CN102643185A
Xun Li, Hengchang Zang, Leilei Shi, “Facile Preparation of 2,3,5-trimethylhydroquinone and method to prevent its oxadation” Patent No: CN102659522A
E-BOOKs
Xun Li, Yalin Li, Wenfang Xu. Recent patents therapeutic agents for cancer. Frontiers in Anti-Cancer Drug Discovery 2010, chapter 28, 623-740. Bentham Publications. (http://bentham.org/ebooks/fiacdd/index.htm)
SELECTED PUBLICATIONS
Leilei Shi, Qiang Wang, Haina Wang, Hua Zhou, Yonggang Li, Xun Li*. Sulphonamide 1,4-dithia-7-azaspiro[4,4]nonane derivatives as gelatinase A inhibitors. Bioorg Med Chem. 2013, doi: http://dx.doi.org/10.1016/j.bmc.2013.10.016 (IF=2.972)
Leilei Shi, Wei Jia, Xun Li*, Ning Jiao*. Cu-catalyzed decarboxylative coupling of propiolic acids with boronic acids. Tetrahedron Lett. 2013, 54(15), 1951-1955. (IF=2.683)
Zheng-gao Shi, Jin-pei Li, Lei-lei Shi, Xun Li*. An updated therapeutic agents targeting MMPs. Recent Patents on Anti-Cancer Drug Discovery. 2012, 7(1), 74-101. (IF=2.368)
Xun Li, Junli Wang, Lei Zhang, Wenfang Xu. Design, synthesis and preliminary activity evaluation of novel peptidomimetics as aminopeptidase N/CD13 inhibitors. Arch Pharm Chem Life Sci, 2011, 344(8), 494-504. (IF=1.529)
Yonggang Li, Jian Zhang, Wenfang Xu, Huawei Zhu, Xun Li*. Novel matrix metalloproteinase inhibitors derived from quinoxalinone scaffold (Part I). Bioorg Med Chem. 2010, 18(4), 1516-1525. (IF=3.072)
Li Y, Yuan H, Yang K, Xu W, Tang W, Li X*. The structure and functions of P-glycoprotein. Curr Med Chem. 2010, 17(8), 786-800. (IF=5.207)
Xun Li*, Jinpei Li. Recent advances in the development of MMPIs and APNIs based on the pyrrolidine platforms. Mini Rev Med Chem. 2010, 10(9), 794-805. (IF=3.268)
Xun Li*, Jifeng Wu. Recent developments in patent anti-cancer agents targeting the matrix metalloproteinases (MMPs). Recent Patents on Anti-Cancer Drug Discovery. 2010, 5(2), 109-141. (IF=2.368)
Xun Li, Junli Wang, Jinpei Li, Jifeng Wu, Yonggang Li, Huawei Zhu, Ruifang Fan, Wenfang Xu*. Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I). Bioorg Med Chem. 2009, 17(8), 3053-3060. (IF=3.072)
Xun Li, Yazhou Wang, Jifeng Wu, Yonggang Li, Qiang Wang, Wenfang Xu*. Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II). Bioorg Med Chem. 2009, 17(8), 3061-3071. (IF=3.072)
Hongyu Yuan, Xun Li*, Xianjun Qu, Lirui Sun, Wenfang Xu and Wei Tang. Synthesis and primary evaluation of quinoxalinone derivatives as potent modulators of multidrug resistance. Med Chem Res. 2009, 18(8), 671-682. (IF=1.058)
Jinpei Li, Ruifang Fan, Yonggang Li, Xun Li*. China’s efforts at avian influenza treatment and prevention. Biosci Trends. 2009, 3(1), 1-2.(IF=0.392)
Yonggang Li, Jifeng Wu, Xun Li*. China makes an impressive breakthrough in avian influenza virus research-discovering the "heart" of avian influenza virus. Drug Discov Ther. 2009, 3(1), 1.
Lirui Sun, Xun Li, Yanna Cheng, Hongyu Yuan, Minghui Chen, Wei Tang, Stephen Geoffrey Ward, Xianjun Qu. Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells. Biomed Pharmacother. 2009, 63(2), 202-208.
Hongyu Yuan, Xun Li*, Jifeng Wu, Jinpei Li, Xianjun Qu, Wenfang Xu, Wei Tang. Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance. Curr Med Chem. 2008, 15(5), 470-476. (IF=5.207)
Xiao-wei Gong, Jin-pei Li, Ji-feng Wu, Xun Li*, Hai-min Zhai, Bo Feng, Wen-fang Xu, Wei Tang. Synthesis of carnitine benzyl esters as prodrugs. J Chem Res. 2008, 27(2), 327-330.(IF=0.550)
Kanghui Yang, Jifeng Wu, Xun Li*. Recent advances in research on P-glycoprotein inhibitors. Biosci Trends. 2008, 2(4), 137-146. (IF=0.392)
Li Xun *. China makes impressive achievements in COPD therapy. Biosci Trends. 2008, 2(3), 94-95. (IF=0.392)
Li Xun *. Tes, a potential Mena-related cancer therapy target. Drug Discov Ther. 2008, 2(1), 1.
Kanghui Yang, Xun Li, Jianzhi Gong, Fang Hao, Wenfang Xu. (S)-2-[(2R,3S)-2-Ammonio-3-hydroxy-3- (4-nitrophenyl)propanamido]-4-methylpentanoate monohydrate. Acta Cryst, 2008, E64, O2447-U3382.
Xun Li*, Jinpei Li, Hongyu Yuan, Xu Gao, Xianjun Qu, Wenfang Xu, Wei Tang. Recent advances in P-gp-mediated multidrug resistance reversal mechanisms. Method Find Exp Clin. 2007, 29(9), 607-617.(IF=1.037)
Jian Liu, Xun Li, Yanna Cheng, Shuxiang Cui, Wenfang Xu, Zhigang Tian, Makuuchi M, Wei Tang, Xianjun Qu. Inhibition of human gastric carcinoma cell growth by treatment of N(3)-o-toluyl-fluorouracil as a precursor of 5-fluorouracil. Eur J Pharmacol. 2007, 574(1):1-7.
Xun Li, Xiaowei Gong, Jinpei Li, Weixia Wang, Wenfang Xu. (R,E)-[4-(Benzyloxy)-2- (cinnamoyloxy)-4-oxobutyl]trimethylammonium chloride hydrochloride. Acta Cryst. 2007, E63, o4239-o4240.(IF=0.413)
Xun Li*, Lingzhong Xu. Dengue aggravation in developing countries in 2007. Biosci Trends. 2007, 1(1), 4. (IF=1.582)
Xun Li*, Kanghui Yang, Xianjun Qu, Wenfang Xu. Advances in the research of quinoxalinone derivatives. Chin J Med Chem. 2007, 17(3), 183-187.
Xun Li, Wenfang Xu*. China’s efforts to shed its title of “Leader in liver disease”. Drug Discov Ther. 2007, 1(2), 84-85.
Xun LI，Kanghui Yang，Xianjun Qu，Wenfang Xu. Advances of the biological activities of quinoxalinone derivatives. QiLu Pharmaceuticals. 2007, 26(1), 34-36.
Xun Li, Yalin Li, Wenfang Xu. Design, synthesis and evaluation of novel galloyl pyrrolidine derivatives as potential anti-tumor agents. Bioorg. Med. Chem. 2006, 14(5), 1287-1293.
Xun Li, Kanghui Yang, Wenfang Xu. Recent advances in the research of quinoxalinone derivatives. Drugs of Future. 2006, 31(11), 979-989.
Xun Li, Wenfang Xu. Recent Patent Therapeutic Agents for Cancer. Recent Patents on Anti-Cancer Drug Discovery. 2006, 1(2), 255-284.
Xun Li, Donghua Wang, Jifeng Wu, Wenfang Xu. A novel regioselective synthesis of substituted 1,3-dimethyl-1H-quinoxalin-2-ones from aniline derivatives. Heterocycles, 2005, 65(11), 2741-2751.
Xun Li, Donghua Wang, Jifeng Wu, Wenfang Xu. Novel approach to 3-methyl-1H-quinoxalin-2-ones. Syn. Commun. 2005, 35(19), 2553-2560.
Xun Li, Junli Wang, Wenfang Xu. Structure confirmation of L-iso-glutamine derivatives. J. Chem.Res. 2005, 2005(2), 94-95.
Xun Li, Wenfang Xu. Synthesis and Crystal Structure of (4S)-5-(2-methoxy-2 -oxoethylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido) Pentanoic Acid①. Chin J Struc Chem 2005, 24(6), 706-710.
Xun Li, Junli Wang, Wenfang Xu. (4S)-4-(methoxycarbonylmethyl aminocarbonyl)-4 -(3,4,5-rimethoxy-benzamido) butanoic acid. Acta Cryst, 2005, E61, O349-O351.
Xun Li. Qingping Hu, Xuegui Cui, Donghua wang. An efficient approach to 6,7-disubstituted-1H-quinoxalin-2-ones Chin. Chem. Lett. 2004, 15(12), 1400-1402.
Xun Li, Qingping Hu, Xuegui Cui, Donghua Wang. An improved synthesis of 6-chloro-2(1H)-quinoxalin. Chin J Org Chem. 2004, 24(7), 767-769.
Xun Li*, Xuegui Cui, Xingang Liu, Xiaofang Li. Bis(ferrocenyl methyl ketone thiosemicarbazone-kappa (2)N,S)zinc tetrahydrofuran hemisolvate. Acta Cryst. 2004, E60, m307-m308.
DonghuaWang, Xun Li, Xingang Liu. Tetra-m-acetato-k8O:O`bis[(2-benzylidene-6,7-dihydro-5H-thiazolo [3,2-a]pyrimidin-3-one-kN)cobalt(II)]. Acta Cryst. 2004, E60, m703-m704.
Xun Li, DonghuaWang, Qingping Hu, Xuegui Cui. Synthesis of 1-allyl-6-chloro-7-methyl-1,4-(2H) quinoxalin-2,3-diones. Fine Chemicals. 2004, 21(7), 519-520.
Xun Li, Qingping Hu, Xuegui Cui, Wenfang Xu. Synthesis of licostinel. Chin J Pharm. 2004, 35(8), 453-454.
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