Center for Synthetic & Chemical Biology,

Key Laboratory of Chemical Biology (Ministry of Education),

School of Pharmaceutical Sciences,

Shandong University,

No. 44 West Wenhua Road,

Jinan, Shandong 250012, P. R. China

Tel: 086-531-88382108 (W),

E-mail: yshen@sdu.edu.cn

Present Position:
Professor of Natural Product Chemistry

Education Background:
1995.10-1999.11: Ph D, Kunming Institute of Botany, Chinese Academy of Sciences (CAS)
1986.09-1989.07: M.Sc., Kunming Institute of Botany, CAS
1982.09-1986.07: B.Sc., Department of chemistry, Anhui Normal University

Professional Experience:
2010.07-Present: Professor, School of Pharmaceutical Sciences, Shandong University
2004.03-2010.06: Professor, School of Life Sciences, Xiamen University
1999.0-2004.02: Professor, Kunming Institute of Botany, CAS
1998.11-1999.06: Associate Professor, Kunming Institute of Botany, CAS
1995.08-1998.08: Visiting Scientist and Ph D student, Department of Chemistry, University of Washington
1991.09-1995.07: Assistant Professor, Kunming Institute of Botany, CAS
1989.09-1991.08: Research Investigator, Kunming Institute of Botany, CAS

Teaching Courses:
Natural Medicinal Chemistry, Organic Spectrum Analysis, Biosynthesis of Natural Products

Research Interests:
(1) Isolation, structure elucidation and biosynthesis of natural products with anti-infectious and antitumor activities from microorganisms, particularly, Actinomycetes.
(2) Mechanism of action and function-orientated structure modifications of anti-infectious and antitumor natural products via medicinal chemistry and synthetic biology approaches.
(3) Research & Development of antitumor and anti-infectious drugs.

Research Grant Support:

·Grand Project of National Natural Science Foundation of China (NSFC) “Novel structure mining and drug discovery-targeted structure optimization of ansamycins” (81530091), sponsored by NSFC from 2016 to 2020 (Principal investigator).

·Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) (IRT13028), sponsored by the Ministry of Education of     China     from 2014 to 2016 (Principal investigator).    

Selected publication of the latest five years (*Corresponding authors)

1 Guoyin Shi, Ning Shi, Yaoyao Li, Wang Chen, Jingjing Deng, Chao Liu, Jing Zhu, Haoxin Wang*, and Yuemao Shen* (2016). D‑Alanylation in the assembly of ansatrienin side chain is catalyzed by a modular NRPS. ACS Chem. Biol. 11, 876−881.

2 Shanren Li, Chunhua Lu, Xiaoyan Chang, and Yuemao Shen* (2016). Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum. Appl. Microbiol. Biotechnol. 100, 2641–2649.

3 Yanjiao Ding, Yaoyao Li, Zhenyu Li, Juanli Zhang, Chunhua Lu, Haoxin Wang, Yuemao Shen*, Liangcheng Du* (2016). Alteramide B is a microtubule antagonist of inhibiting Candida albicans. Biochim. Biophys. Acta 1860, 2097–2106.

4 Zhixing Guo, Xiaoli Li, Jianfang Li, Xuefei Yang, Yuan Zhou, Chunhua Lu*, and Yuemao Shen* (2016). Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium. Biochem. Biophys. Res. Commun. 477, 998–1004.

5 Chuanpeng Liang, Huilin Hao, Xingkang Wu, Zhenyu Li, Jing Zhu, Chunhua Lu, and Yuemao Shen* (2016). Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors. Eur. J. Med. Chem. 121, 272–282.

6 Yong Han, Yan Wang, Simon Tombosa, Stephen Wright, Justin Huffman, Gary Yuen, Guoliang Qian, Fengquan Liu, Yuemao Shen*, Liangcheng Du*. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Appl. Microbiol. Biotechnol. 2015, 99, 801-8111.

7 Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Guowei Shi, Chunhua Lu, Yuemao Shen*. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors. Chem. Biol. Drug Des. 2015, 85, 181-188.

8 Yaoyao Li, Haotong Chen, Yanjiao Ding, Yunxuan Xie, Haoxin Wang, Ronald L. Cerny, Yuemao Shen*, Liangcheng Du*. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF. Angew. Chem. Int. Edit. 2014, 53, 7524-7530.

9 Zhenyu Li, Lejiao Jia, Jifeng Wang, Xingkang Wu, Huilin Hao, Yunfei Wu, Hongjiao Xu, Zhen Wang, Guowei Shi, Chunhua Lu, Yuemao Shen*. Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors. Eur. J. Med. Chem. 2014, 87, 346-363.

10 Shanren Li, Haoxin Wang, Yaoyao Li, Jingjing Deng, Chunhua Lu, Yan Shen, Yuemao Shen*. Biosynthesis of hygrocins, antitumor naphthoquinone ansamycins produced by Streptomyces sp. LZ35. ChemBioChem 2014, 15, 94-102.

11 Jianfang Li, Chao Lv, Weiyang Sun, Zhenyu Li, Xiaowei Han, Yaoyao Li, Yuemao Shen*. Cytosporone B, an inhibitor of the Type III secretion system of Salmonella enterica Serovar Typhimurium. Antimicrob. Agents Chemother. 2013, 57, 2191-2198.

12 Jifeng Wang, Baobing Zhao, Yuting Yi, Wei Zhang, Xuan Wu, Lianru Zhang, Yuemao Shen*. Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways. Biochem. Pharm. 2012, 84, 891-899.

13 Baobing Zhao, Huili Shen, Lianru Zhang, Yuemao Shen*. Gambogic acid activates AMP-activated protein kinase in mammalian cells. Biochem. Biophys. Res. Commun. 2012, 424, 100-104.

14 Yaoyao Li, Justin Huffman, Yu Li, Liangcheng Du*, Yuemao Shen*. 3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF from Lysobacter enzymogenes C3. Med. Chem. Commun. 2012, 3, 982-986.