Curriculum Vitae

Fengshan WANG, Ph.D, Professor

ADDRESS:

Institute of Biochemical and Biotechnological Drug

School of Pharmaceutical Sciences, Cheeloo College of Medicine

Shandong University

No.44, Wenhuaxi Road, Jinan, 250012

P.R.China

Tel: 0086-531-88382658

Fax: 0086-531-88382548

E-mail: fswang@sdu.edu.cn

EDUCATION:

1998--2001: East China University of Science and Technology, Shanghai, Ph.D. in Biochemical Engineering.

1983--1986: Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, M.S. in Biopharmacy.

1978--1982: Department of Pharmacy, Shandong Medical College, Jinan, Shandong, B.S. in Pharmacy.

PROFESSIONAL EXPERIENCE:

2020-present：Executive Director, Institute of Regulatory Science for Medicall Products, Shandong University

2015-2020: Vice Dean, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

2007-2016: Dean, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.

2007-present: Vice Director, National Glycoengineering Research Center, Shandong University, Jinan, Shandong, China.

1998- present: Director, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Science, Shandong University, Jinan, Shandong, China.

1994-1998:    Associate Professor, Department of Biopharmacy, Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, China.

1995–1996:   Visiting Scholar, Department of Chemistry, Imperial College of Science Technology and Medicine, London, England.

1988-1994:    Lecturer, Department of Biopharmacy, Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, China.

1986-1994:    Teaching Assistant, Department of Biopharmacy, Faculty of Pharmacy, Shandong Medical University, Jinan, Shandong, China.

RESEARCH INTERESTS:

Biochemical and biotechnological drugs; gene cloning and expression; chemical and biotechnological modification of proteins and enzymes; polysaccharides.

SCIENTIFIC, HONARARY AND PROFESSIONAL SOCIETIES:

2020-present：Society of Glyco-Drugs, China Biochemical Pharmaceutical Industry Association.

2007-present: Associate Chairman of Specialty Committee of Biochemical and Biotechnological Pharmaceuticals, Chinese Pharmaceutical Association.

2010-present: Honorary Chairman of Industrial Branch of Chinese Society of Biochemistry & Molecular Biology.

2002-present: Chairman of Expert Committee, China Biochemical Pharmaceutical Industry Association.

SELECTED PUBLICATION:

1. Fei Liu, Jinhua Zhang, Linjun Zhang, Mengqi Diao, Peixue Ling*, Fengshan Wang*. Correlation between the synthesis of pullulan and melanin in Aureobasidium pullulans. International Journal of Biological Macromolecules, 2021, 177: 252–260.

2. Qingyue Liu, Yi Tan, Tingyu Qu, Jianhui Zhang, Xuexia Duan, Hongpeng Xu, Yue Mu, Heran Ma*, Fengshan Wang*. Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro. Life Sciences, 2020, 254: 117772.

3. Dake Hao, Yahan Fan, Wenwu Xiao, Ruiwu Liu, Christopher Pivetti, Tanaya Walimbe, Fuzheng Guo, Xinke Zhang, Diana L Farmer, Fengshan Wang, Alyssa Panitch, Kit S Lam, Aijun Wang*. Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells. Acta Biomaterialia, 2020, 108: 178-193.

4. Lu Lu, Hongyuan Chen, Longkun Wang, Lin Zhao, Yanna Cheng, Aijun Wang, Fengshan Wang*, Xinke Zhang*. A Dual Receptor Targeting- and BBB PenetratingPeptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma. International Journal of Nanomedicine, 2020, 15: 8875–8892.

5. Congcong Chen, Shuaishuai Wang, Madhusudhan Reddy Gadi, He Zhu, Fei Liu, Chang-Cheng Liu*, Lei Li*, Fengshan Wang*, Peixue Ling*, Hongzhi Cao *. Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives. Chem. Commun., 2020, 56: 7549-7552. 

6. Yiming Jin, Yue Mu, Shuhan Zhang, Pingli Li*, Fengshan Wang*. Preparation and evaluation of the adjuvant effect of curdlan sulfate in improving the efficacy of dendritic cell-based vaccine for antitumor immunotherapy. International Journal of Biological Macromolecules, 2020, 146: 273-284.

7. Shu Zhang, Honglei Jiang, Shengshi Huang, Pingli Li, Fengshan Wang*. Curdlan sulfate/O-linked quaternized chitosan nanoparticles acting as potential adjuvants promote multiple arms of immune responses. Carbohydrate Polymers, 2019, 213: 100-111.

8. L. X. Zang, R. R. Du, H. C. Zang, F. S. Wang*, J. Z. Sheng*. Production of Arabidopsis thaliana UDP-Sugar Pyrophosphorylase by Pichia pastoris and Its Application in Efficient UDP-Glucose and UDP-Glucuronic Acid Synthesis. Applied Biochemistry and Microbiology, 2019, 55(6): 631–638.

9. Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi, Xian-Wei Liu, Guofeng Gu, Shu-Qi Wang, Jie Zhao, Ping Wang, Min Xiao, Fengshan Wang, Hongzhi Cao*. Reprogramming the enzymatic assembly line for site-specific fucosylation. Nature Catalys, 2019, 2: 514-522.

10. Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang*, Fengshan Wang*. The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems. Asian Journal of Pharmaceutical Sciences, 2019, 14: 595–608.

11. Wenjie Jiang, Yanna Cheng, Na Zhao, Lian Li, Yikang Shi, Aizhen Zong, Fengshan Wang*. Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells. International Journal of Biological Macromolecules, 2018, 107: 349–362.

12. Yi-Jun Li, Feng-Xin Yin, Xin-Ke Zhang, Jie Yu, Shuang Zheng, Xin-Lei Song, Feng-Shan Wang, Ju-Zheng Sheng*. Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018, 1862 (3): 547-556.

13. Shu Zhang, Shengshi Huang, Lu Lu, Xinlei Song, Pingli Li, Fengshan Wang*. Curdlan sulfate–O-linked quaternized chitosan nanoparticles: potential adjuvants to improve the immunogenicity of exogenous antigens via intranasal vaccination. International Journal of Nanomedicine, 2018, 13: 2377-2394.

14. Caicai Meng, Aniruddha Sasmal, Yan Zhang, Tian Gao, Chang-Cheng Liu, Naazneen Khan, Ajit Varki, Fengshan Wang*, Hongzhi Cao*. Chemoenzymatic Assembly of mammalian O-mannose glycans. Angew. Chem. Int. Ed. 2018, 57, 9003-9007.

15. Yiming Jin, Pingli Li, Fengshan Wang*.b-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties. Vaccine, 2018, 36: 5235-5244.

16. Qixin Chen, Chengzhi Jin, Xintian Shao, Ruilin Guan, Zhiqi Tian, Chenran Wang, Fei Liu,Peixue Ling, Jun-Lin Guan, Liangnian Ji, Fengshan Wang*, Hui Chao*, Jiajie Diao*. Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore. Small, 2018, 14: 1802166.

17. Xintian Shao, Qixin Chen, Xixi Dou, Lei Chen, Jixu Wu, Wei Zhang, Huarong Shao, Peixue Ling*, Fei Liu*, Fengshan Wang*. Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway. Carbohydrate Polymers, 2018, 198: 354–363.

18. Fuyan Liu,  Xiaofeng Zhang, Yuqiu Li, Hui Gao, Peixue Ling*, Xiaoyan Li, Qixin Chen, Aibin Ma, Huarong Shao, Mei Li, Fengshan Wang*. Simultaneous Screening and Determination of Eight Tetracycline Antibiotics Illegally Adulterated in Herbal Preparations Using HPLC-DAD Combined with LC-MS-MS. Chromatographia, 2018, 81 (36):303-314.

19. Qixin Chen, Xintian Shao, Peixue Ling*, Fei Liu, Huarong Shao, Aibin Ma, Jixu Wu, Wei Zhang, Fuyan Liu, Guanying Han*, Fengshan Wang*. Low molecular weight xanthan gum suppresses oxidative stress-induced apoptosis in rabbit chondrocytes. Carbohydrate Polymers, 2017, 169:  255–263.

20. Feng-Xin Yin, Feng-Shan Wang*, Ju-Zheng Sheng*. Uncovering the Catalytic Direction of Chondroitin AC Exolyase. FROM THE REDUCING END TOWARDS THE NON-REDUCING END*. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291(9): 4399–4406.

21. Yan Li, Lian Li, Zhiwei Li, Juzheng Sheng, Xinke Zhang, Danyang Feng, Xu Zhang, Fengxin Yin, Aijun Wang, Fengshan Wang*. Tat PTD- Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops. Biochimica et Biophysica Acta-General Subject, 2016, 1860: 2137–2147.

22. Yuliang Xiao, Pingli Li, Yanna Cheng, Qian Zhang, FengshanWang*. Effect of a-linolenic acid-modified low molecular weight chondroitin sulfate on atherosclerosis in apoE-deficient mice. Biochimica et Biophysica Acta-General Subject, 2016, 1860: 2589–2597.

23. Xinlei Song, Shu Zhang, Yanna Cheng, Ting Zhao, Qianqian Lian, Lu Lu, Fengshan Wang*. Experimental Study on the Efficacy of Site-Specific PEGylated Human Serum Albumins in Resuscitation from Hemorrhagic Shock. Crit Care Med, 2016, 44(11): e1090-e1096.

24. Yan Zhang, Caicai Meng, Lan Jin, Xi Chen, Fengshan Wang*, Hongzhi Cao*. Chemoenzymatic synthesis of a-dystroglycan core M1 O-mannose glycans†. Chem. Commun., 2015, 51: 11654-11657.

25. Pingli Li, Xinke Zhang, Yanna Cheng, Juan Li, Yuliang Xiao, Qian Zhang,Aizhen Zong, Chuanqing Zhong, Fengshan Wang*. Preparation and in vitro immunomodulatory effect of curdlan sulfate. Carbohydrate Polymers, 2014, 102: 852– 861.

26. Xin Meng, Wenlong Yao, Jiansong Cheng, Xu Zhang, Lan Jin, Hai Yu, Xi Chen, Fengshan Wang*, Hongzhi Cao*. Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes. J. Am. Chem. Soc., 2014, 136, 5205−5208.

27. Jingzong Qi, Qingli Wang, Zhenhang Yu, Xin Chen and Fengshan Wang*.  Innovative drug R&D in China. Nature Reviews Drug Discovery, 2011, 10(5): 333-334.   

* Correspondence author.